rs4073582

A SNP in the CNIH2 gene on chromosome 11. Its most notable genotype is A;A: lower risk for gout

Gene
CNIH2
Location
Chr 1166,283,241 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodlower risk for goutWorth knowing · 2.03% of people
  2. A;GBadslightly higher risk for goutMinor · 1.525% of people
  3. G;GBadslightly higher risk for goutMinor · 1.972% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 3% A;G 25% G;G 72%
  • European ancestry (Utah)A;A 15% A;G 45% G;G 40%
  • Han Chinese (Beijing)A;A 0% A;G 7% G;G 93%
  • Japanese (Tokyo)A;A 0% A;G 9% G;G 91%
  • Yoruba (Nigeria)A;A 0% A;G 6% G;G 94%
  • African ancestry (Southwest US)A;A 0% A;G 18% G;G 83%
  • Chinese (Denver)A;A 0% A;G 8% G;G 92%
  • Gujarati IndianA;A 4% A;G 39% G;G 57%
  • Luhya (Kenya)A;A 0% A;G 17% G;G 84%
  • Mexican ancestry (Los Angeles)A;A 3% A;G 40% G;G 57%
  • Maasai (Kenya)A;A 2% A;G 30% G;G 68%
  • TuscanA;A 9% A;G 52% G;G 39%

Conditions, medicines and genes

Notes

From SNPedia

Notes

gout association, based on

A;G

About 20% of any population have this genotype, which is at 1.5x higher risk for developing gout than the quite rare (A;A) genotype for this SNP.

G;G

Although ~80% of almost any group of people are of this genotype, it is associated with about twice the risk for developing gout as are people with the (A;A) genotype for this SNP.

Source and license

Adapted from rs4073582 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.