rs4077515

A SNP in the CARD9 gene on chromosome 9. Its most notable genotype is C;C: common in clinvar

Gene
CARD9
Location
Chr 9136,372,044 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
37%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodcommon in clinvarTypical · 0.044% of people

SNPedia records rs4077515 on the minus strand: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 44%
  • European ancestry (Utah)C;C 26%
  • Han Chinese (Beijing)C;C 50%
  • Japanese (Tokyo)C;C 50%
  • Yoruba (Nigeria)C;C 57%
  • African ancestry (Southwest US)C;C 44%
  • Chinese (Denver)C;C 51%
  • Gujarati IndianC;C 34%
  • Luhya (Kenya)C;C 53%
  • Mexican ancestry (Los Angeles)C;C 22%
  • Maasai (Kenya)C;C 59%
  • TuscanC;C 35%

Other CARD9 SNPs

All CARD9 SNPs

Notes

From SNPedia

Notes

Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP. Elucidating the chromosome 9 association with AS; CARD9 is a candidate gene. An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians. The interaction effect of rs4077515 and rs17019602 increases the susceptibility to IgA nephropathy

Source and license

Adapted from rs4077515 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.