rs4140564

A SNP on chromosome 1. Its most notable genotype is A;A: common in complete genomics

Gene
None listed
Location
Chr 1186,755,871 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
4%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodcommon in complete genomicsTypical · 0.093% of people

SNPedia records rs4140564 on the minus strand: (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A 93%
  • European ancestry (Utah)A;A 86%
  • Han Chinese (Beijing)A;A 100%
  • Japanese (Tokyo)A;A 100%
  • Yoruba (Nigeria)A;A 87%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs4140564, a SNP on chromosome 1 near the PTGS2 and PLA2G4A genes, has been associated with knee osteoarthritis. A study of 255 British patients, replicated subsequently in ~2,000 UK, Dutch and US patients, found that rs4140564 was associated with knee osteoarthritis in all populations studied with an overall odds ratio = 1.55, CI: 1.30-1.85, p < 6.9 x 10e-7.

Source and license

Adapted from rs4140564 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.