rs4148941

A SNP in the CHST3 gene on chromosome 10. Its most notable genotype is A;C: Slightly higher (1.5) risk for lumbar disc disease (?)

Gene
CHST3
Location
Chr 1072,009,234 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodcommon/normalTypical · 0.042% of people
  2. A;CMost notableBadSlightly higher (1.5) risk for lumbar disc disease (?)Minor · 1.541% of people
  3. C;CBadSlightly higher (1.5) risk for lumbar disc disease (?)Minor · 1.517% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageA;A 42% A;C 41% C;C 17%
  • European ancestry (Utah)A;A 43% A;C 45% C;C 13%
  • Han Chinese (Beijing)A;A 18% A;C 54% C;C 28%
  • Japanese (Tokyo)A;A 15% A;C 53% C;C 32%
  • Yoruba (Nigeria)A;A 88% A;C 10% C;C 2%
  • Chinese (Denver)A;A 18% A;C 48% C;C 34%
  • Gujarati IndianA;A 26% A;C 52% C;C 23%
  • Luhya (Kenya)A;A 86% A;C 14% C;C 0%
  • Mexican ancestry (Los Angeles)A;A 34% A;C 54% C;C 13%
  • Maasai (Kenya)A;A 54% A;C 42% C;C 4%
  • TuscanA;A 35% A;C 43% C;C 22%

Conditions, medicines and genes

Other CHST3 SNPs

All CHST3 SNPs

Notes

From SNPedia

Notes

aka c.*763C>A Possible risk factor for lumbar disc disease, based on a study of 4,000 patients; the AA and AC genotypes had an odds ratio of ~1.5 for developing the disorder. However, note that this variant is annotated as benign by the one submitter (Illumina) to ClinVar, whether for skeletal dysplasia or similar syndromes.

A;C

see discussion at main rs-page

C;C

see discussion at main rs-page

Source and license

Adapted from rs4148941 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.