rs4149056(C;C)

17x myopathy risk for statin users

Magnitude
3.2Important
Repute
Bad
Frequency
1%Average of 11 populations
On SNPedia
rs4149056(C;C)
Gene
SLCO1B1

Frequency

Share of people with C;C in each HapMap population.

  • Tuscan4%
  • Chinese (Denver)3%
  • Japanese (Tokyo)3%
  • Maasai (Kenya)2%
  • African ancestry (Southwest US)2%
  • Han Chinese (Beijing)2%
  • European ancestry (Utah)<1%
  • Yoruba (Nigeria)0%
  • Gujarati Indian0%
  • Luhya (Kenya)0%
  • Mexican ancestry (Los Angeles)0%

Other genotypes of rs4149056

  1. C;TBadreduced breakdown of some drugs; 5x increased myopathy risk for statin usersWorth knowing · 2.116% of people
  2. T;TGoodnormalTypical · 0.082% of people

All about rs4149056

Notes

From SNPedia

reduced breakdown of some drugs; CPIC Recommendation: Prescribe a lower dose (20mg daily) or consider an alternative statin (e.g., pravastatin or rosuvastatin); consider routine creatine kinase (CK) surveillance. significantly associated with myopathy in patients who received simvastatin, but not in patients who received atorvastatin. PMID 21243006 however it did not affect pravastatin.

References

Source and license

Adapted from rs4149056(C;C) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.