rs4254535

A SNP on chromosome 2. Its most notable genotype is T;T: common in complete genomics

Gene
None listed
Location
Chr 268,971,256 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
30%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. T;TMost notableGoodcommon in complete genomicsTypical · 0.050% of people

On SNPedia: (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 50%
  • European ancestry (Utah)T;T 47%
  • Han Chinese (Beijing)T;T 50%
  • Japanese (Tokyo)T;T 50%
  • Yoruba (Nigeria)T;T 39%
  • African ancestry (Southwest US)T;T 35%
  • Chinese (Denver)T;T 56%
  • Gujarati IndianT;T 63%
  • Luhya (Kenya)T;T 36%
  • Mexican ancestry (Los Angeles)T;T 61%
  • Maasai (Kenya)T;T 48%
  • TuscanT;T 60%

Notes

From SNPedia

Notes

Genome-wide significant association between a sequence variant at 15q15.2 and lung cancer risk. In this study, we sought to confirm 7 variants with suggestive association to lung cancer (P < 10(-5)) in a recently published meta-analysis. In a GWA dataset of 1,447 lung cancer cases and 36,256 controls in Iceland, 3 correlated variants on 15q15.2 (rs504417, rs11853991, and rs748404) showed a significant association with lung cancer, whereas rs4254535 on 2p14, rs1530057 on 3p24.1, rs6438347 on 3q13.31, and rs1926203 on 10q23.31 did not.

Source and license

Adapted from rs4254535 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.