rs4290

A SNP on chromosome 17. Its most notable genotype is C;C: normal

Gene
None listed
Location
Chr 1763,474,767 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe
Minor allele frequency
5%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodnormalTypical · 0.088% of people
  2. C;TNot ratedhigher cardiovascular risk in African AmericansTypical · 0.010% of people
  3. T;TNot ratedhigher cardiovascular risk in African AmericansTypical · 0.02% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageC;C 88% C;T 10% T;T 2%
  • European ancestry (Utah)C;C 100% C;T 0% T;T 0%
  • Han Chinese (Beijing)C;C 100% C;T 0% T;T 0%
  • Japanese (Tokyo)C;C 100% C;T 0% T;T 0%
  • Yoruba (Nigeria)C;C 51% C;T 41% T;T 8%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs7213516 and rs4290 are SNPs located 2-3 kb upstream of the angiotensin I-converting enzyme (ACE) gene, and therefore potentially of regulatory importance. In a study in which 1,000 hypertensive individuals participating in the International Verapamil SR Trandolapril Study Genetic Substudy (INVEST-GENES) were tested for associations with adverse cardiovascular outcomes, both rs4290 and rs7213516 were associated with higher risk. The higher allele frequencies for the risk alleles in African Americans compared to Hispanics and Caucasians suggests that these alleles may contribute to ethnic-specific variation in risk.

Source and license

Adapted from rs4290 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.