rs4307059

A SNP on chromosome 5. Its most notable genotype is T;T: 1.42x risk of Autism

Gene
None listed
Location
Chr 525,967,594 (GRCh38)
Highest magnitude
3.0Important
Tested on
23andMe, AncestryDNA
Minor allele frequency
24%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodReduced Autism riskWorth knowing · 2.06% of people
  2. C;TBad1.19x risk of AutismWorth knowing · 2.026% of people
  3. T;TMost notableBad1.42x risk of AutismImportant · 3.068% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 6% C;T 26% T;T 68%
  • European ancestry (Utah)C;C 12% C;T 50% T;T 38%
  • Han Chinese (Beijing)C;C 3% C;T 24% T;T 74%
  • Japanese (Tokyo)C;C <1% C;T 27% T;T 73%
  • Yoruba (Nigeria)C;C 0% C;T 0% T;T 100%
  • African ancestry (Southwest US)C;C 0% C;T 11% T;T 90%
  • Chinese (Denver)C;C <1% C;T 26% T;T 73%
  • Gujarati IndianC;C 17% C;T 47% T;T 37%
  • Luhya (Kenya)C;C 0% C;T <1% T;T 99%
  • Mexican ancestry (Los Angeles)C;C 11% C;T 32% T;T 58%
  • Maasai (Kenya)C;C 3% C;T 26% T;T 72%
  • TuscanC;C 16% C;T 51% T;T 34%

Conditions, medicines and genes

Notes

From SNPedia

Notes

23andMe blog rs4307059 &#8212; compared to two copies of a C, each copy of the more common T version increased the odds of autism by 1.19 times. dx.doi.org

C;T

Slightly increased risk of Autism due to worse brain cell adhesion.

T;T

Worse cell adhesion in neurons.ncbi.nlm.nih.gov Increased risk of Autism Spectrum Disorders.

Source and license

Adapted from rs4307059 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.