rs4324715

A SNP on chromosome 5. Its most notable genotype is C;C: >1.5x increased testicular cancer risk for men

Gene
None listed
Location
Chr 5142,289,942 (GRCh38)
Highest magnitude
1.2Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
35%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBad>1.5x increased testicular cancer risk for menMinor · 1.248% of people
  2. C;TBad1.5x increased testicular cancer risk for menMinor · 1.140% of people
  3. T;TNot ratedNormal risk of testicular cancer.Minor · 1.013% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 48% C;T 40% T;T 13%
  • European ancestry (Utah)C;C 40% C;T 43% T;T 18%
  • Han Chinese (Beijing)C;C 59% C;T 37% T;T 4%
  • Japanese (Tokyo)C;C 52% C;T 39% T;T 9%
  • Yoruba (Nigeria)C;C 65% C;T 31% T;T 4%
  • African ancestry (Southwest US)C;C 53% C;T 40% T;T 7%
  • Chinese (Denver)C;C 52% C;T 42% T;T 6%
  • Gujarati IndianC;C 21% C;T 51% T;T 29%
  • Luhya (Kenya)C;C 73% C;T 25% T;T 3%
  • Mexican ancestry (Los Angeles)C;C 33% C;T 40% T;T 28%
  • Maasai (Kenya)C;C 56% C;T 43% T;T 1%
  • TuscanC;C 20% C;T 50% T;T 30%

Conditions, medicines and genes

Notes

From SNPedia

Notes

Testicular germ cell tumor risk I("TGCT"; i.e. testicular cancer risk) was increased 40% per copy of the major (T) allele at rs4324715 and rs6897876 (OR = 1.37, CI: 1.14–1.64; OR = 1.39, CI: 1.16–1.66, respectively), based on a genome-wide scan of 277 primarily Caucasian TGCT cases and 919 controls. Men who have two copies of the common version of the sprouty 4 SPRY4 gene have a 1.5-fold higher risk of testicular cancer than men who have two copies of the less common or minor version of the gene. [doi|10.1038/ng.393]

Source and license

Adapted from rs4324715 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.