rs4349859

A SNP in the MICA gene on chromosome 6. Its most notable genotype is A;A: likely to carry two HLA-B27 alleles, possible risk for B27 Syndromes.

Gene
MICA
Location
Chr 631,398,010 (GRCh38)
Highest magnitude
3.0Important
Tested on
23andMe, AncestryDNA
Minor allele frequency
2%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadlikely to carry two HLA-B27 alleles, possible risk for B27 Syndromes.Important · 3.00% of people
  2. A;GBadlikely to carry one HLA-B27 allele, possible risk for B27 Syndromes.Important · 3.01% of people
  3. G;GGoodcommon in complete genomicsTypical · 0.099% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A 0% A;G 1% G;G 99%
  • European ancestry (Utah)A;A 0% A;G 5% G;G 95%
  • Han Chinese (Beijing)A;A 0% A;G 0% G;G 100%
  • Japanese (Tokyo)A;A 0% A;G 0% G;G 100%
  • Yoruba (Nigeria)A;A 0% A;G 0% G;G 100%

Other MICA SNPs

All MICA SNPs

Notes

From SNPedia

Notes

Is there a higher genetic load of susceptibility loci in familial ankylosing spondylitis?

A;A

See details at: HLA-B27 Syndromes. Not all allelles of HLA-B27 are at risk for B27 Syndromes, please check the HLA-B27 page for details.

A;G

See details at: HLA-B27 Syndromes. Not all allelles of HLA-B27 are at risk for B27 Syndromes, please check the HLA-B27 page for details.

Source and license

Adapted from rs4349859 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.