rs438034

A SNP in the CENPF gene on chromosome 1. Its most notable genotype is G;G: normal

Gene
CENPF
Location
Chr 1214,657,274 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
38%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratednormalTypical · 0.041% of people
  2. A;GNot ratedpoorer survival rate if breast cancer patientTypical · 0.040% of people
  3. A;ANot ratedpoorer survival rate if breast cancer patientTypical · 0.019% of people

SNPedia records rs438034 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 41% A;G 40% A;A 19%
  • European ancestry (Utah)G;G 30% A;G 47% A;A 23%
  • Han Chinese (Beijing)G;G 82% A;G 18% A;A 0%
  • Japanese (Tokyo)G;G 80% A;G 20% A;A <1%
  • Yoruba (Nigeria)G;G 10% A;G 56% A;A 34%
  • African ancestry (Southwest US)G;G 7% A;G 47% A;A 46%
  • Chinese (Denver)G;G 86% A;G 13% A;A <1%
  • Gujarati IndianG;G 54% A;G 44% A;A 3%
  • Luhya (Kenya)G;G 12% A;G 40% A;A 48%
  • Mexican ancestry (Los Angeles)G;G 45% A;G 45% A;A 10%
  • Maasai (Kenya)G;G 12% A;G 55% A;A 33%
  • TuscanG;G 34% A;G 51% A;A 15%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs438034 is a SNP in the centromere protein F CENPF gene. Based on a long-term (up to 15 years) study of 749 Swedish women with breast cancer, carriers of rs438034(T) alleles (as oriented wrt dbSNP) had poorer specific survival rates as compared to rs438034(C;C) individuals. The hazard ratio was 2.65 (CI: 1.19-5.90). However, although rs438034(T) carriers had worse survival odds, they were less likely to have either regional lymph node metastases (odds ratio 0.71, CI: 0.51-1.01) or tumors of stage II-IV (OR 0.73, CI 0.54-0.99).

Source and license

Adapted from rs438034 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.