rs4538475

A SNP in the BST1 gene on chromosome 4. Its most notable genotype is G;G: Increased risk of developing Parkinson's Disease

Gene
BST1
Location
Chr 415,736,314 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
31%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodNormal risk of developing Parkinson's DiseaseMinor · 1.044% of people
  2. A;GBadSlightly increased risk of developing Parkinson's DiseaseMinor · 1.541% of people
  3. G;GMost notableBadIncreased risk of developing Parkinson's DiseaseWorth knowing · 2.015% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 44% A;G 41% G;G 15%
  • European ancestry (Utah)A;A 70% A;G 29% G;G <1%
  • Han Chinese (Beijing)A;A 24% A;G 52% G;G 24%
  • Japanese (Tokyo)A;A 16% A;G 48% G;G 36%
  • Yoruba (Nigeria)A;A 42% A;G 45% G;G 13%
  • African ancestry (Southwest US)A;A 46% A;G 47% G;G 7%
  • Chinese (Denver)A;A 19% A;G 44% G;G 37%
  • Gujarati IndianA;A 58% A;G 34% G;G 8%
  • Luhya (Kenya)A;A 60% A;G 33% G;G 7%
  • Mexican ancestry (Los Angeles)A;A 47% A;G 45% G;G 9%
  • Maasai (Kenya)A;A 30% A;G 47% G;G 23%
  • TuscanA;A 76% A;G 23% G;G 2%

Other BST1 SNPs

All BST1 SNPs

Source and license

Adapted from rs4538475 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.