rs4647269
A SNP in the MLH1 gene on chromosome 3. Its most notable genotype is C;C: common in clinvar
- Gene
- MLH1
- Location
- Chr 337,016,100 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- AncestryDNA
- Minor allele frequency
- 30%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 60%
- European ancestry (Utah)C;C 23%
- Han Chinese (Beijing)C;C 86%
- Japanese (Tokyo)C;C 68%
- Yoruba (Nigeria)C;C 62%
- African ancestry (Southwest US)C;C 44%
- Chinese (Denver)C;C 90%
- Gujarati IndianC;C 60%
- Luhya (Kenya)C;C 64%
- Mexican ancestry (Los Angeles)C;C 43%
- Maasai (Kenya)C;C 85%
- TuscanC;C 32%
Related
Other MLH1 SNPs
- rs11541859G;TLynch syndrome, pathogenic mutationVery important
- rs35001569A;TLynch syndrome, pathogenic mutationVery important
- rs41542214C;TLynch syndromeVery important
- rs63749795C;TLynch syndrome, pathogenic mutationVery important
- rs63749804-;CLynch syndrome, pathogenic mutationVery important
- rs63749813-;GALynch syndrome, pathogenic mutationVery important
- rs63749816-;CLynch syndrome, pathogenic mutationVery important
- rs63749818A;CLynch syndrome, pathogenic mutationVery important
Source and license
Adapted from rs4647269 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.