rs4656461

A SNP on chromosome 1. Its most notable genotype is G;G: 2.2x increased risk for open angle glaucoma

Gene
None listed
Location
Chr 1165,717,968 (GRCh38)
Highest magnitude
2.2Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
14%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ANot ratednormalTypical · 0.071% of people
  2. A;GBad1.5x increased risk for open angle glaucomaMinor · 1.526% of people
  3. G;GMost notableBad2.2x increased risk for open angle glaucomaWorth knowing · 2.23% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageA;A 71% A;G 26% G;G 3%
  • European ancestry (Utah)A;A 74% A;G 24% G;G 3%
  • Han Chinese (Beijing)A;A 99% A;G <1% G;G 0%
  • Japanese (Tokyo)A;A 99% A;G <1% G;G 0%
  • Yoruba (Nigeria)A;A 59% A;G 35% G;G 6%
  • African ancestry (Southwest US)A;A 54% A;G 42% G;G 4%
  • Gujarati IndianA;A 94% A;G 6% G;G 0%
  • Luhya (Kenya)A;A 43% A;G 48% G;G 9%
  • Mexican ancestry (Los Angeles)A;A 59% A;G 41% G;G 0%
  • Maasai (Kenya)A;A 48% A;G 44% G;G 8%
  • TuscanA;A 78% A;G 22% G;G 0%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs4656461 is a SNP near the TMCO1 gene. A (GWA) study for open-angle glaucoma (OAG) blindness ultimately based on ~1500 cases concluded that the rather rare rs4656461(G) allele was statistically associated with the condition, with a per allele odds ratio of 1.5 (CI: 1.35&#8211;1.68, p = 6 &#215; 10e?14).

Source and license

Adapted from rs4656461 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.