rs4681

A SNP in the FGB gene on chromosome 4. Its most notable genotype is C;C: common in clinvar

Gene
FGB
Location
Chr 4154,569,680 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
16%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodcommon in clinvarTypical · 0.076% of people

On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 76%
  • European ancestry (Utah)C;C 66%
  • Han Chinese (Beijing)C;C 62%
  • Japanese (Tokyo)C;C 77%
  • Yoruba (Nigeria)C;C 97%
  • African ancestry (Southwest US)C;C 91%
  • Chinese (Denver)C;C 54%
  • Gujarati IndianC;C 65%
  • Luhya (Kenya)C;C 99%
  • Mexican ancestry (Los Angeles)C;C 60%
  • Maasai (Kenya)C;C 95%
  • TuscanC;C 67%

Other FGB SNPs

All FGB SNPs

Source and license

Adapted from rs4681 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.