rs4686484

A SNP in the LPP gene on chromosome 3. Its most notable genotype is A;A: slightly increased risk for celiac disease

Gene
LPP
Location
Chr 3188,400,784 (GRCh38)
Highest magnitude
1.2Minor
Tested on
Not on consumer chips
Minor allele frequency
38%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadslightly increased risk for celiac diseaseMinor · 1.2
  2. A;GNot ratedneutral/commonTypical · 0.0
  3. G;GGoodslightly decreased risk for celiac diseaseMinor · 1.2

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other LPP SNPs

All LPP SNPs

Notes

From SNPedia

Notes

rs4686484 is a SNP in the LPP gene. The LPP protein is involved in cell motility and cell–cell adhesion, which is crucial to maintaining the barrier integrity of epithelial monolayers such as those in the small intestine. A study of several populations eventually settled on rs4686484 as the SNP most likely to be the functional variant at the heart of the haplotypes associated with altered risk for celiac disease. The rarer rs4686484(G) allele is less common in patients than in healthy controls, and it is therefore thought to have a (slight) protective role, leading to reduced risk for the disorder.

Source and license

Adapted from rs4686484 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.