rs4712653

A SNP in the LINC00340 gene on chromosome 6. Its most notable genotype is C;C: Slightly (~1.6x) increased risk for neuroblastoma

Gene
LINC00340
Location
Chr 622,125,735 (GRCh38)
Highest magnitude
1.6Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
35%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadSlightly (~1.6x) increased risk for neuroblastomaMinor · 1.652% of people
  2. C;TBadvery slightly (~1.3x) increased risk for neuroblastomaMinor · 1.338% of people
  3. T;TGoodcommon/normalTypical · 0.010% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 52% C;T 38% T;T 10%
  • European ancestry (Utah)C;C 17% C;T 51% T;T 32%
  • Han Chinese (Beijing)C;C 54% C;T 35% T;T 10%
  • Japanese (Tokyo)C;C 47% C;T 49% T;T 4%
  • Yoruba (Nigeria)C;C 78% C;T 21% T;T <1%
  • African ancestry (Southwest US)C;C 73% C;T 27% T;T 0%
  • Chinese (Denver)C;C 62% C;T 30% T;T 7%
  • Gujarati IndianC;C 34% C;T 54% T;T 12%
  • Luhya (Kenya)C;C 71% C;T 28% T;T <1%
  • Mexican ancestry (Los Angeles)C;C 50% C;T 40% T;T 10%
  • Maasai (Kenya)C;C 63% C;T 34% T;T 3%
  • TuscanC;C 21% C;T 53% T;T 27%

Conditions, medicines and genes

Other LINC00340 SNPs

All LINC00340 SNPs

Notes

From SNPedia

Notes

SNPs clustered in one region of chromosome 6p22 have been linked to increased risk for the exceedingly rare childhood cancer known as neuroblastoma. A study involving 720 patients determined that rs4712653(C;C) genotypes had increased likelihood of neuroblastoma development (odds ratio 1.35, CI: 1.24 to 1.46, p= 5.5 x 10e13). At-risk homozygotes diagnosed with neuroblastoma had, on average, more malignant clinical presentation, more aggressive disease, and poorer long-term survival. For more information on this cluster of SNPs, see rs6939340. Common variations in BARD1 influence susceptibility to high-risk neuroblastoma.

Source and license

Adapted from rs4712653 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.