rs4730751
A SNP in the CAV1 gene on chromosome 7. Its most notable genotype is A;A: For kidney donors, 2x more likely to result in allograft rejection
- Gene
- CAV1
- Location
- Chr 7116,540,796 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 16%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableNot ratedFor kidney donors, 2x more likely to result in allograft rejection
- A;CNot ratedNo summary available.
- C;CNot ratedNo summary available.
On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageA;A 5% A;C 19% C;C 75%
- European ancestry (Utah)A;A 8% A;C 39% C;C 54%
- Han Chinese (Beijing)A;A 0% A;C 4% C;C 96%
- Japanese (Tokyo)A;A 0% A;C 0% C;C 100%
- Yoruba (Nigeria)A;A 13% A;C 35% C;C 52%
Related
Notes
From SNPedia
Notes
rs4730751 is a SNP in the gene for CAV1, a protein that is involved in tissue fibrosis as well as vascular proliferation. In a study of 785 white kidney transplant donors and their respective recipients, kidneys from rs4730751(A;A) donors were significantly more likely to fail the transplant, compared with those from donors carrying one or two of the more common rs4730751(C) alleles. The hazard ratio was 1.97 (CI: 1.29-3.16, p = 0.002). Overall, the graft failure rate for donor kidneys with the (A;A) genotype was 38.6%, compared with ~22% for donor genotypes (A;C) or (C;C).
Source and license
Adapted from rs4730751 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.