rs4763655

A SNP in the KLRB1 gene on chromosome 12. Its most notable genotype is A;A: >1.10x risk

Gene
KLRB1
Location
Chr 129,602,982 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
34%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot rated>1.10x riskTypical · 0.013% of people
  2. A;GNot rated1.10x riskTypical · 0.039% of people
  3. G;GNot ratedcommonTypical · 0.048% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 13% A;G 39% G;G 48%
  • European ancestry (Utah)A;A 12% A;G 42% G;G 46%
  • Han Chinese (Beijing)A;A 19% A;G 53% G;G 27%
  • Japanese (Tokyo)A;A 14% A;G 52% G;G 34%
  • Yoruba (Nigeria)A;A <1% A;G 28% G;G 72%
  • African ancestry (Southwest US)A;A 5% A;G 21% G;G 74%
  • Chinese (Denver)A;A 22% A;G 50% G;G 28%
  • Gujarati IndianA;A 20% A;G 57% G;G 23%
  • Luhya (Kenya)A;A 4% A;G 23% G;G 73%
  • Mexican ancestry (Los Angeles)A;A 24% A;G 45% G;G 31%
  • Maasai (Kenya)A;A 3% A;G 17% G;G 80%
  • TuscanA;A 15% A;G 45% G;G 41%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs4763655 has been reported in a large study to be associated with multiple sclerosis. The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with this allele is 1.10 (CI 1.04-1.17).

Source and license

Adapted from rs4763655 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.