rs4822492

A SNP in the ADORA2A-AS1 gene on chromosome 22. Its most notable genotype is C;C: increased anxiety in response to caffeine

Gene
ADORA2A-AS1
Location
Chr 2224,447,626 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
48%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedincreased anxiety in response to caffeineWorth knowing · 2.030% of people
  2. C;GNot ratedNo summary available.Typical · 0.045% of people
  3. G;GNot ratedNo summary available.Typical · 0.025% of people

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageC;C 30% C;G 45% G;G 25%
  • European ancestry (Utah)C;C 12% C;G 54% G;G 34%
  • Han Chinese (Beijing)C;C 24% C;G 44% G;G 31%
  • Japanese (Tokyo)C;C 18% C;G 48% G;G 34%
  • Yoruba (Nigeria)C;C 65% C;G 35% G;G 0%

Conditions, medicines and genes

Other ADORA2A-AS1 SNPs

All ADORA2A-AS1 SNPs

Notes

From SNPedia

Notes

Variation at this SNP, rs4822492, appears to influence how an individual responds to moderate levels (150mg) of caffeine.

C;C

associated with increased anxiety in response to caffeine

References

Source and license

Adapted from rs4822492 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.