rs4845378
A SNP in the CHRNB2 gene on chromosome 1. Its most notable genotype is G;G: common in clinvar
- Gene
- CHRNB2
- Location
- Chr 1154,572,175 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 11%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in one HapMap population.
- Yoruba (Nigeria)G;G 100%
Notes
From SNPedia
Notes
Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta. Assessment of Alzheimer's disease case-control associations using family-based methods. Intermediate phenotypes identify divergent pathways to Alzheimer's disease.
Source and license
Adapted from rs4845378 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.