rs4867568

A SNP in the LOC105374701 gene on chromosome 5. Its most notable genotype is C;T: decreased risk of knee osteoporosis

Gene
LOC105374701
Location
Chr 528,549,074 (GRCh38)
Highest magnitude
1.2Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CNot ratedno decreased risk of knee osteoporosisMinor · 1.036% of people
  2. C;TMost notableGooddecreased risk of knee osteoporosisMinor · 1.248% of people
  3. T;TGoodDecreased risk for knee osteoporosisMinor · 1.216% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 36% C;T 48% T;T 16%
  • European ancestry (Utah)C;C 20% C;T 58% T;T 21%
  • Han Chinese (Beijing)C;C 47% C;T 42% T;T 10%
  • Japanese (Tokyo)C;C 45% C;T 42% T;T 13%
  • Yoruba (Nigeria)C;C 44% C;T 43% T;T 13%
  • African ancestry (Southwest US)C;C 44% C;T 42% T;T 14%
  • Chinese (Denver)C;C 39% C;T 49% T;T 13%
  • Gujarati IndianC;C 17% C;T 63% T;T 20%
  • Luhya (Kenya)C;C 41% C;T 46% T;T 14%
  • Mexican ancestry (Los Angeles)C;C 22% C;T 55% T;T 22%
  • Maasai (Kenya)C;C 48% C;T 35% T;T 17%
  • TuscanC;C 28% C;T 55% T;T 18%

Conditions, medicines and genes

Notes

From SNPedia

Notes

A 2017 article performed a genome-wide association study (GWAS) of tibiofemoral knee OA in 3,898 cases and 3,168 controls from 4 well-characterized North American cohorts, and performed replication. Reduction of risk of knee osteoarthritis for T allele: OR at 0.84

Source and license

Adapted from rs4867568 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.