rs4895441
A SNP in the LOC105378010 gene on chromosome 6. Its most notable genotype is A;A: common in clinvar
- Gene
- LOC105378010
- Location
- Chr 6135,105,435 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 23%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 66%
- European ancestry (Utah)A;A 59%
- Han Chinese (Beijing)A;A 51%
- Japanese (Tokyo)A;A 41%
- Yoruba (Nigeria)A;A 90%
- African ancestry (Southwest US)A;A 72%
- Chinese (Denver)A;A 45%
- Gujarati IndianA;A 73%
- Luhya (Kenya)A;A 91%
- Mexican ancestry (Los Angeles)A;A 59%
- Maasai (Kenya)A;A 87%
- TuscanA;A 53%
Notes
From SNPedia
Show notes, about 120 words
Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults. Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia. DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease. Genetic complexity in sickle cell disease. Genetic variation on chromosome 6 influences F cell levels in healthy individuals of African descent and HbF levels in sickle cell patients. Sickle Cell Disease in the Post Genomic Era: A Monogenic Disease with a Polygenic Phenotype.
Source and license
Adapted from rs4895441 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.