rs4911414

A SNP on chromosome 20. Its most notable genotype is G;T: 2-4x higher risk of sun sensitivity if part of risk haplotype

Gene
None listed
Location
Chr 2034,141,638 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
23%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GGoodnormalTypical · 0.065% of people
  2. G;TMost notableBad2-4x higher risk of sun sensitivity if part of risk haplotypeWorth knowing · 2.030% of people
  3. T;TBad2-4x higher risk of sun sensitivity if part of risk haplotypeWorth knowing · 2.05% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 65% G;T 30% T;T 5%
  • European ancestry (Utah)G;G 46% G;T 45% T;T 9%
  • Han Chinese (Beijing)G;G 77% G;T 20% T;T 3%
  • Japanese (Tokyo)G;G 56% G;T 35% T;T 10%
  • Yoruba (Nigeria)G;G 73% G;T 26% T;T 1%
  • African ancestry (Southwest US)G;G 70% G;T 28% T;T 2%
  • Chinese (Denver)G;G 63% G;T 30% T;T 7%
  • Gujarati IndianG;G 77% G;T 22% T;T 1%
  • Luhya (Kenya)G;G 81% G;T 18% T;T <1%
  • Mexican ancestry (Los Angeles)G;G 45% G;T 48% T;T 7%
  • Maasai (Kenya)G;G 81% G;T 18% T;T 1%
  • TuscanG;G 47% G;T 44% T;T 9%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 180 words

rs4911414 is a SNP near the ASIP (agouti signaling protein) gene on chromosome 20. This SNP is one of a tightly-linked pair that increases the likelihood of an individual being prone to sun sensitivity, in other words, freckles and sunburn, based on a study of 6,000+ Caucasians (5,000+ Icelanders + 1,000+ Dutch). The odds ratios, presumably on a dominant basis, and at least in the largest population (Icelanders) for "freckles and burns vs. no freckles and tans" for the haplotype pair rs1015362(G) - rs4911414(T) is 3.91 (CI: 2.54-6.03) for males and 2.42 (CI: 1.52-3.86) for females, with an overall p=0.051. Based on a study by the same authors of 4,000+ skin cancer patients, this haplotype was seen to confer significant increased risk for cutaneous malignant melanoma (odds ratio 1.45, p = 1.2 x 10 -9 ) as well as basal cell carcinoma (odds ratio 1.33, p = 1.2 x 10 -6 ). Melanoma susceptibility variants on chromosome 20q11.22 are associated with pigmentary traits and the risk of nonmelanoma skin cancer. Web-based, participant-driven studies yield novel genetic associations for common traits.

Source and license

Adapted from rs4911414 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.