rs4915077

A SNP in the VAV3 gene on chromosome 1. Its most notable genotype is C;C: Higher risk of hypothyroidism

Gene
VAV3
Location
Chr 1107,823,394 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
14%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadHigher risk of hypothyroidismWorth knowing · 2.03% of people
  2. T;TNot ratedNo summary available.Typical · 0.078% of people

On SNPedia: (C;C), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 3% T;T 78%
  • European ancestry (Utah)C;C <1% T;T 87%
  • Han Chinese (Beijing)C;C 7% T;T 51%
  • Japanese (Tokyo)C;C 12% T;T 43%
  • Yoruba (Nigeria)C;C 0% T;T 95%
  • African ancestry (Southwest US)C;C 0% T;T 97%
  • Chinese (Denver)C;C 6% T;T 59%
  • Gujarati IndianC;C 2% T;T 82%
  • Luhya (Kenya)C;C 0% T;T 95%
  • Mexican ancestry (Los Angeles)C;C 2% T;T 68%
  • Maasai (Kenya)C;C 0% T;T 91%
  • TuscanC;C 0% T;T 89%

Source and license

Adapted from rs4915077 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.