rs4921
A SNP in the POLR2E gene on chromosome 19. Its most notable genotype is C;C: common in complete genomics
- Gene
- POLR2E
- Location
- Chr 191,093,980 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, FamilyTreeDNA
- Minor allele frequency
- 1%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs4921 on the minus strand: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 3 HapMap populations.
- AverageC;C 96%
- European ancestry (Utah)C;C 96%
- Gujarati IndianC;C 97%
- TuscanC;C 95%
Source and license
Adapted from rs4921 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.