rs4939883

A SNP in the LOC105372112 gene on chromosome 18. Its most notable genotype is C;C: associated with higher HDL cholesterol

Gene
LOC105372112
Location
Chr 1849,640,844 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
23%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodassociated with higher HDL cholesterolMinor · 1.559% of people
  2. C;TGoodassociated with higher HDL cholesterolMinor · 1.533% of people

On SNPedia: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 59% C;T 33%
  • European ancestry (Utah)C;C 65% C;T 33%
  • Han Chinese (Beijing)C;C 62% C;T 35%
  • Japanese (Tokyo)C;C 64% C;T 32%
  • Yoruba (Nigeria)C;C 23% C;T 51%
  • African ancestry (Southwest US)C;C 42% C;T 42%
  • Chinese (Denver)C;C 66% C;T 32%
  • Gujarati IndianC;C 80% C;T 19%
  • Luhya (Kenya)C;C 34% C;T 50%
  • Mexican ancestry (Los Angeles)C;C 91% C;T 9%
  • Maasai (Kenya)C;C 53% C;T 42%
  • TuscanC;C 74% C;T 25%

Conditions, medicines and genes

Other LOC105372112 SNPs

All LOC105372112 SNPs

Notes

From SNPedia

Notes

C allele is associated with 1.87mg/dl increase in HDL cholesterol (good cholesterol).

Source and license

Adapted from rs4939883 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.