rs4950

A SNP in the CHRNB3 gene on chromosome 8. Its most notable genotype is A;A: Most common genotype in several populations; yet also higher leadership occupancy?

Gene
CHRNB3
Location
Chr 842,697,490 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
36%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodMost common genotype in several populations; yet also higher leadership occupancy?Minor · 1.043% of people

SNPedia records rs4950 on the minus strand: (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 43%
  • European ancestry (Utah)A;A 60%
  • Han Chinese (Beijing)A;A 53%
  • Japanese (Tokyo)A;A 75%
  • Yoruba (Nigeria)A;A 5%
  • African ancestry (Southwest US)A;A 9%
  • Chinese (Denver)A;A 64%
  • Gujarati IndianA;A 56%
  • Luhya (Kenya)A;A 5%
  • Mexican ancestry (Los Angeles)A;A 71%
  • Maasai (Kenya)A;A 10%
  • TuscanA;A 66%

Other CHRNB3 SNPs

All CHRNB3 SNPs

Notes

From SNPedia

Show notes, about 120 words

One paper published in 2013 (and not replicated since then to our knowledge), titled "Born to Lead? A Twin Design and Genetic Association Study of Leadership Role Occupancy", performed a GWAS study that concluded that leadership role occupancy is associated with rs4950, a SNP in the neuronal acetylcholine receptor gene (CHRNB3). Individuals with the rs4950(T;T) genotype (as oriented in dbSNP and SNPedia) are statistically more likely (odds ratio ~1.5) to occupy leadership positions as compared to rs4950(C;T) or (C;C) individuals. Popular news about this finding includes: http://www.sciencedaily.com/releases/2013/01/130115111553.htm and https://www.23andme.com/you/community/thread/16689/

A;A

see text on main rs-page

Source and license

Adapted from rs4950 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.