rs4969168
A SNP in the SOCS3 gene on chromosome 17. Its most notable genotype is A;A: Obesity and/or Insulin resistance associations
- Gene
- SOCS3
- Location
- Chr 1778,357,712 (GRCh38)
- Highest magnitude
- 2.3Worth knowing
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 35%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 21%
- European ancestry (Utah)A;A <1%
- Han Chinese (Beijing)A;A 21%
- Japanese (Tokyo)A;A 18%
- Yoruba (Nigeria)A;A 50%
- African ancestry (Southwest US)A;A 35%
- Chinese (Denver)A;A 17%
- Gujarati IndianA;A 7%
- Luhya (Kenya)A;A 46%
- Mexican ancestry (Los Angeles)A;A 5%
- Maasai (Kenya)A;A 24%
- TuscanA;A 2%
Notes
From SNPedia
Notes
Elevated expression and genetic association links the SOCS3 gene to atopic dermatitis. Elevated expression and polymorphisms of SOCS3 influence patient response to antiviral therapy in chronic hepatitis C. Lack of association between the tagging SNP A+930-->G of SOCS3 and type 2 diabetes mellitus: meta-analysis of four independent study populations. Gene expression and hepatitis C virus infection. Polymorphisms near SOCS3 are associated with obesity and glucose homeostasis traits in Hispanic Americans from the Insulin Resistance Atherosclerosis Family Study.
A;A
Possible associations with metabolic syndrome related traits - obesity, BMI, VAT, weight, insulin resistance
Source and license
Adapted from rs4969168 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.