rs4977756

A SNP in the CDKN2BAS gene on chromosome 9. Its most notable genotype is G;G: 1.93x higher risk for glioma development

Gene
CDKN2BAS
Location
Chr 922,068,653 (GRCh38)
Highest magnitude
1.4Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
30%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;GBad1.39x higher risk for glioma developmentMinor · 1.242% of people
  2. G;GMost notableBad1.93x higher risk for glioma developmentMinor · 1.410% of people

On SNPedia: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;G 42% G;G 10%
  • European ancestry (Utah)A;G 48% G;G 18%
  • Han Chinese (Beijing)A;G 32% G;G 6%
  • Japanese (Tokyo)A;G 31% G;G 8%
  • Yoruba (Nigeria)A;G 48% G;G 8%
  • African ancestry (Southwest US)A;G 49% G;G 4%
  • Chinese (Denver)A;G 33% G;G 4%
  • Gujarati IndianA;G 49% G;G 11%
  • Luhya (Kenya)A;G 47% G;G 13%
  • Mexican ancestry (Los Angeles)A;G 26% G;G 2%
  • Maasai (Kenya)A;G 49% G;G 27%
  • TuscanA;G 52% G;G 7%

Conditions, medicines and genes

Other CDKN2BAS SNPs

All CDKN2BAS SNPs

Notes

From SNPedia

Notes

rs4977756 is a SNP near the CDKN2BAS gene. A (GWA) study for open-angle glaucoma (OAG) blindness ultimately based on ~1500 cases concluded that the rather common rs4977756(A) allele was statistically associated with the condition, with a per allele odds ratio of 1.39 (CI: 1.28–1.51, p = 1.35 × 10e?14).

Source and license

Adapted from rs4977756 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.