rs4979462

A SNP in the TNFSF15 gene on chromosome 9. Its most notable genotype is T;T: Increased risk of developing primary biliary cirrhosis

Gene
TNFSF15
Location
Chr 9114,804,733 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
20%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodNormal risk of developing primary biliary cirrhosisMinor · 1.061% of people
  2. C;TBadSlightly increased risk of developing primary biliary cirrhosisMinor · 1.531% of people
  3. T;TMost notableBadIncreased risk of developing primary biliary cirrhosisWorth knowing · 2.08% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 61% C;T 31% T;T 8%
  • European ancestry (Utah)C;C 99% C;T 2% T;T 0%
  • Han Chinese (Beijing)C;C 52% C;T 38% T;T 10%
  • Japanese (Tokyo)C;C 31% C;T 44% T;T 25%
  • Yoruba (Nigeria)C;C 37% C;T 48% T;T 15%
  • African ancestry (Southwest US)C;C 54% C;T 39% T;T 7%
  • Chinese (Denver)C;C 62% C;T 34% T;T 5%
  • Gujarati IndianC;C 95% C;T 5% T;T 0%
  • Luhya (Kenya)C;C 33% C;T 52% T;T 16%
  • Mexican ancestry (Los Angeles)C;C 66% C;T 33% T;T 2%
  • Maasai (Kenya)C;C 44% C;T 44% T;T 12%
  • TuscanC;C 99% C;T 1% T;T 0%

Source and license

Adapted from rs4979462 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.