rs498872

A SNP in the PHLDB1 gene on chromosome 11. Its most notable genotype is A;A: 1.4x higher risk for glioma development

Gene
PHLDB1
Location
Chr 11118,606,652 (GRCh38)
Highest magnitude
1.4Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
23%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GNot ratedNo summary available.Typical · 0.062% of people
  2. A;GBad1.2x higher risk for glioma developmentMinor · 1.232% of people
  3. A;AMost notableBad1.4x higher risk for glioma developmentMinor · 1.46% of people

SNPedia records rs498872 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 62% A;G 32% A;A 6%
  • European ancestry (Utah)G;G 49% A;G 40% A;A 11%
  • Han Chinese (Beijing)G;G 57% A;G 34% A;A 10%
  • Japanese (Tokyo)G;G 63% A;G 31% A;A 6%
  • Yoruba (Nigeria)G;G 87% A;G 13% A;A 0%
  • African ancestry (Southwest US)G;G 73% A;G 27% A;A 0%
  • Chinese (Denver)G;G 39% A;G 51% A;A 10%
  • Gujarati IndianG;G 33% A;G 52% A;A 16%
  • Luhya (Kenya)G;G 82% A;G 18% A;A 0%
  • Mexican ancestry (Los Angeles)G;G 60% A;G 32% A;A 9%
  • Maasai (Kenya)G;G 87% A;G 12% A;A 1%
  • TuscanG;G 54% A;G 43% A;A 3%

Conditions, medicines and genes

Notes

From SNPedia

Notes

23andMe blog rs498872 A 1.18 Glioma

Source and license

Adapted from rs498872 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.