rs5036

A SNP in the SLC4A1 gene on chromosome 17. Its most notable genotype is C;T: Memphis variant of erythrocyte Band 3 glycoprotein

Gene
SLC4A1
Location
Chr 1744,261,577 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
7%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TGoodcommon in clinvarTypical · 0.085% of people
  2. C;TMost notableNot ratedMemphis variant of erythrocyte Band 3 glycoproteinWorth knowing · 2.014% of people

SNPedia records rs5036 on the minus strand: (A;A), (A;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 85% C;T 14%
  • European ancestry (Utah)T;T 94% C;T 6%
  • Han Chinese (Beijing)T;T 84% C;T 15%
  • Japanese (Tokyo)T;T 70% C;T 26%
  • Yoruba (Nigeria)T;T 86% C;T 14%
  • African ancestry (Southwest US)T;T 83% C;T 16%
  • Chinese (Denver)T;T 89% C;T 11%
  • Gujarati IndianT;T 98% C;T 2%
  • Luhya (Kenya)T;T 76% C;T 23%
  • Mexican ancestry (Los Angeles)T;T 81% C;T 19%
  • Maasai (Kenya)T;T 78% C;T 21%
  • TuscanT;T 96% C;T 4%

Other SLC4A1 SNPs

All SLC4A1 SNPs

Notes

From SNPedia

Notes

aka c.166A>G (p.Lys56Glu or K56E) This variant is known as the Memphis variant of the Band 3 glycoprotein, and it is found in perhaps 5-15% of individuals across various ethnicities. It is reported in ClinVar as likely to be benign, although some publications do cite some variation in anion transport in erythrocytes due to this (Memphis) variant.

C;T

Thought to be mostly benign; see text and links via main rs-page.

Source and license

Adapted from rs5036 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.