rs526934
A SNP in the TCN1 gene on chromosome 11. Its most notable genotype is A;A: common/normal
- Gene
- TCN1
- Location
- Chr 1159,866,020 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 22%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 64%
- European ancestry (Utah)A;A 49%
- Han Chinese (Beijing)A;A 64%
- Japanese (Tokyo)A;A 72%
- Yoruba (Nigeria)A;A 79%
- African ancestry (Southwest US)A;A 68%
- Chinese (Denver)A;A 69%
- Gujarati IndianA;A 62%
- Luhya (Kenya)A;A 82%
- Mexican ancestry (Los Angeles)A;A 59%
- Maasai (Kenya)A;A 57%
- TuscanA;A 47%
Notes
From SNPedia
Notes
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway. G allele associated with lower serum Vitamin B12. "The TCN1 rs526934 G variant may reduce transport of cobalamin, resulting in lower plasma vitamin B12 levels." This large study (over 50,000 people) found no evidence for "positive association of homocysteine or negative associations of folate and vitamin B12 with CAD/MI".
Source and license
Adapted from rs526934 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.