rs5335
A SNP in the EDNRA gene on chromosome 4. Its most notable genotype is C;C: normal risk
- Gene
- EDNRA
- Location
- Chr 4147,542,688 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 50%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CMost notableNot ratednormal risk
- C;GBad1.19x risk for hypertension
- G;GBad>1.19x risk for hypertension
On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageC;C 26% C;G 49% G;G 24%
- European ancestry (Utah)C;C 19% C;G 50% G;G 31%
- Han Chinese (Beijing)C;C 16% C;G 53% G;G 31%
- Japanese (Tokyo)C;C 22% C;G 49% G;G 29%
- Yoruba (Nigeria)C;C 49% C;G 44% G;G 6%
Notes
From SNPedia
Notes
rs5335, a SNP in the EDNRA gene, has been associated with a (slightly) increased risk for hypertension, based on a study of ~1400 Caucasians. The odds ratio per (G) allele is 1.19 (CI: 1.00-1.41, p=0.05). A role for endothelin receptor type A in migraine without aura susceptibility? A study in Portuguese patients.
Source and license
Adapted from rs5335 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.