rs5351

A SNP in the EDNRB gene on chromosome 13. Its most notable genotype is T;T: common in clinvar

Gene
EDNRB
Location
Chr 1377,901,178 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
45%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableGoodcommon in clinvarTypical · 0.022% of people

SNPedia records rs5351 on the minus strand: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 22%
  • European ancestry (Utah)T;T 15%
  • Han Chinese (Beijing)T;T 43%
  • Japanese (Tokyo)T;T 21%
  • Yoruba (Nigeria)T;T 17%
  • African ancestry (Southwest US)T;T 25%
  • Chinese (Denver)T;T 43%
  • Gujarati IndianT;T 19%
  • Luhya (Kenya)T;T 21%
  • Mexican ancestry (Los Angeles)T;T 20%
  • Maasai (Kenya)T;T 12%
  • TuscanT;T 8%

Conditions, medicines and genes

Other EDNRB SNPs

All EDNRB SNPs

Notes

From SNPedia

Notes

In 630 patients with essential hypertension (EHT) among males significant differences in rs5351 and rs5333 influencing atherosclerosis

Source and license

Adapted from rs5351 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.