rs5746059

A SNP in the TNFRSF1B gene on chromosome 1. Its most notable genotype is A;A: Slightly higher fat mass

Gene
TNFRSF1B
Location
Chr 112,202,735 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
15%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadSlightly higher fat massMinor · 1.576% of people
  2. A;GBadSlightly higher fat massMinor · 1.522% of people
  3. G;GGoodnormalTypical · 0.02% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 76% A;G 22% G;G 2%
  • European ancestry (Utah)A;A 53% A;G 43% G;G 4%
  • Han Chinese (Beijing)A;A 64% A;G 31% G;G 6%
  • Japanese (Tokyo)A;A 73% A;G 26% G;G 2%
  • Yoruba (Nigeria)A;A 97% A;G 3% G;G 0%
  • African ancestry (Southwest US)A;A 91% A;G 9% G;G 0%
  • Chinese (Denver)A;A 65% A;G 34% G;G <1%
  • Gujarati IndianA;A 67% A;G 26% G;G 7%
  • Luhya (Kenya)A;A 96% A;G 4% G;G 0%
  • Mexican ancestry (Los Angeles)A;A 81% A;G 19% G;G 0%
  • Maasai (Kenya)A;A 93% A;G 6% G;G <1%
  • TuscanA;A 60% A;G 38% G;G 2%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs5746059 is a SNP in the tumor necrosis factor-alpha receptor 2 TNFRSF1B gene. A study of ~1,800 subjects from 400 Caucasian families concluded that carriers of a rs5746059(A) allele had a 4.6% higher fat mass and a 2.5% increased percentage fat mass compared to noncarriers; the results were significant after multiple testing correction. This same correlation was also seen in 700 independent Chinese Han adults and 1,000 additional Caucasians. This SNP therefore appears to be associated with risk for obesity.

Source and license

Adapted from rs5746059 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.