rs578776

A SNP in the CHRNA3 gene on chromosome 15. Its most notable genotype is G;G: common in clinvar

Gene
CHRNA3
Location
Chr 1578,596,058 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
46%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableGoodcommon in clinvarTypical · 0.020% of people

SNPedia records rs578776 on the minus strand: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 20%
  • European ancestry (Utah)G;G 57%
  • Han Chinese (Beijing)G;G 4%
  • Japanese (Tokyo)G;G 4%
  • Yoruba (Nigeria)G;G 12%
  • African ancestry (Southwest US)G;G 11%
  • Chinese (Denver)G;G 5%
  • Gujarati IndianG;G 26%
  • Luhya (Kenya)G;G 8%
  • Mexican ancestry (Los Angeles)G;G 21%
  • Maasai (Kenya)G;G 23%
  • TuscanG;G 52%

Conditions, medicines and genes

Other CHRNA3 SNPs

All CHRNA3 SNPs

Notes

From SNPedia

Show notes, about 380 words

identifies a region associated with nicotine dependence in this particular study (1,050 dependents, 879 non-dependent controls, all of European descent), noted as distinct from the loci which rs16969968 defines Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Variants in nicotinic receptors and risk for nicotine dependence. Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence. Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research. Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer. Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smoking. Nicotinic receptor gene variants influence susceptibility to heavy smoking. A testable prognostic model of nicotine dependence. Genome-wide and candidate gene association study of cigarette smoking behaviors. Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes. Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5. Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes. Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population. Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance. Association of the nicotine metabolite ratio and CHRNA5/CHRNA3 polymorphisms with smoking rate among treatment-seeking smokers. Single nucleotide polymorphisms in CHRNA5 rs16969968, CHRNA3 rs578776, and LOC123688 rs8034191 are associated with heaviness of smoking in women in Northeastern Ontario, Canada. Genetic polymorphisms in 15q25 and 19q13 loci, cotinine levels, and risk of lung cancer in EPIC. Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits.

Source and license

Adapted from rs578776 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.