rs58542926
A SNP in the TM6SF2 gene on chromosome 19. Its most notable genotype is C;T: Complex; slightly lower risk of heart attacks, yet slightly higher risk for diabetes and NAFLD
- Gene
- TM6SF2
- Location
- Chr 1919,268,740 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CGoodcommon/normal
- C;TMost notableNot ratedComplex; slightly lower risk of heart attacks, yet slightly higher risk for diabetes and NAFLD
On SNPedia: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Notes
From SNPedia
Notes
Known more commonly as the TM6SF2 E167K variant, but also as c.499C>T or p.Glu167Lys, rs58542926 is a highly studied variant in the TM6SF2 gene located on chromosome 19. Summarizing many studies conducted over the last 10+ years: TM6SF2 E167K variant carriers, i.e. rs58542926(C) carriers, have lower total cholesterol levels, lower prevalence of carotid atherosclerotic plaques and a (slightly; ~0.90x) lower incidence of cardiovascular events, however, they also have a (slightly) increased risk of developing non-alcoholic fatty liver disease and diabetes. Several reviews of TM6SF2 biology can be readily found, including the 2018 article,
C;T
see text on main rs-page
Source and license
Adapted from rs58542926 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.