rs58596362
A SNP in the LMNA gene on chromosome 1. Its most notable genotype is C;T: Progeria - but more likely a technical/lab error
- Gene
- LMNA
- Location
- Chr 1156,138,613 (GRCh38)
- Highest magnitude
- 4.0Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other LMNA SNPs
- rs56699480C;TEmery-Dreifuss Muscular DystrophyVery important
- rs57207746A;GEmery-Dreifuss Muscular DystrophyVery important
- rs58048078A;TEmery-Dreifuss Muscular DystrophyVery important
- rs60934003C;TEmery-Dreifuss Muscular DystrophyVery important
- rs61046466C;TEmery-Dreifuss Muscular DystrophyVery important
- rs267607539C;GEmery-Dreifuss Muscular DystrophyVery important
- rs267607540-;GAAEmery-Dreifuss Muscular DystrophyVery important
- rs878853220G;TEmery-Dreifuss Muscular DystrophyVery important
Notes
From SNPedia
Notes
rs58596362, also known as c.1824C>T and p.Gly608=, represents a rare mutation in the LMNA gene on chromosome 1. The rare rs58596362(T) allele is reported to act as an autosomal dominant mutation leading to Hutchinson-Gilford progeria. However, this allele has been reported in data from 23andMe patients who lack progeria symptoms, so it seems likely that this is due to a technical error. See also OMIM 150330.0022
C;T
While this should indicate progeria, 23andMe is incorrectly reporting this for many users. see additional discussion at rs58596362
Source and license
Adapted from rs58596362 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.