rs587777892
A SNP in the LMNA gene on chromosome 1. Its most notable genotype is G;T: Charcot-Marie-Tooth disease possibility
- Gene
- LMNA
- Location
- Chr 1156,136,008 (GRCh38)
- Highest magnitude
- 4.0Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (G;G), (G;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other LMNA SNPs
- rs56699480C;TEmery-Dreifuss Muscular DystrophyVery important
- rs57207746A;GEmery-Dreifuss Muscular DystrophyVery important
- rs58048078A;TEmery-Dreifuss Muscular DystrophyVery important
- rs60934003C;TEmery-Dreifuss Muscular DystrophyVery important
- rs61046466C;TEmery-Dreifuss Muscular DystrophyVery important
- rs267607539C;GEmery-Dreifuss Muscular DystrophyVery important
- rs267607540-;GAAEmery-Dreifuss Muscular DystrophyVery important
- rs878853220G;TEmery-Dreifuss Muscular DystrophyVery important
Notes
From SNPedia
Notes
rs587777892 is a heterozygous 1044G>T nucleotide change in the LMNA gene. The nucleotide change predicts an amino acid substitution of methionine to isoleucine at amino acid residue 348 (M3481 or Met348Ile), and it is considered in the article cited below to be a causative (and autosomal dominant) change leading to Charcot-Marie-Tooth disease. http://phenomena.nationalgeographic.com/2014/08/19/how-an-extreme-athlete-uncovered-her-own-genetic-flaw/
G;T
Do you have this genotype? If so, please contact SNPedia at . Also, see discussion and article at the SNPedia rs587777892 page.
Source and license
Adapted from rs587777892 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.