rs587782958
A SNP in the MYBPC3 gene on chromosome 11. Its most notable genotype is C;T: Likely miscall in 23andMe v5 data; otherwise, familial hypertrophic cardiomyopathy possible
- Gene
- MYBPC3
- Location
- Chr 1147,333,552 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- C;TMost notableBadLikely miscall in 23andMe v5 data; otherwise, familial hypertrophic cardiomyopathy possible
- C;CGoodcommon in clinvar
SNPedia records rs587782958 on the minus strand: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other MYBPC3 SNPs
- rs397515963C;CLikely severe cardiomyopathyVery important
- rs200411226C;THypertrophic CardiomyopathyVery important
- rs375882485A;Gfamilial hypertrophic cardiomyopathy mutationVery important
- rs786204338C;GHypertrophic CardiomyopathyVery important
- rs1060501474G;THypertrophic CardiomyopathyVery important
- rs111683277C;TFamilial Hypertrophic CardiomyopathyVery important
- rs111729952C;TFamilial Hypertrophic CardiomyopathyVery important
- rs113358486A;CFamilial Hypertrophic CardiomyopathyVery important
Notes
From SNPedia
Notes
rs587782958, also known as c.3190+5G>A, represents a variant in the MYBPC3 gene on chromosome 11. The rare minor allele of this variant is reported to be pathogenic/likely pathogenic for familial hypertrophic cardiomyopathy (HCM), according to . Note: the minor allele of this SNP appears to be prone to false positive (miscalls) on the 23andMe v5 chip.
C;T
23andMe v5 data appears to have a high false positive (miscall) rate for this genotype, and you are far more likely to actually be rs587782958(G;G), assuming your data is from that platform. Otherwise:
Source and license
Adapted from rs587782958 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.