rs58922911
A SNP in the LMNA gene on chromosome 1. Its most notable genotype is G;T: Likely miscall by 23andMe (and other genotyping companies); otherwise, dominant cardiomyopathy mutation
- Gene
- LMNA
- Location
- Chr 1156,115,094 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe
Genotypes
As shown in 23andMe and AncestryDNA files.
- G;TMost notableGoodLikely miscall by 23andMe (and other genotyping companies); otherwise, dominant cardiomyopathy mutation
- T;TGoodcommon in clinvar
On SNPedia: (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other LMNA SNPs
- rs56699480C;TEmery-Dreifuss Muscular DystrophyVery important
- rs57207746A;GEmery-Dreifuss Muscular DystrophyVery important
- rs58048078A;TEmery-Dreifuss Muscular DystrophyVery important
- rs60934003C;TEmery-Dreifuss Muscular DystrophyVery important
- rs61046466C;TEmery-Dreifuss Muscular DystrophyVery important
- rs267607539C;GEmery-Dreifuss Muscular DystrophyVery important
- rs267607540-;GAAEmery-Dreifuss Muscular DystrophyVery important
- rs878853220G;TEmery-Dreifuss Muscular DystrophyVery important
Notes
From SNPedia
Show notes, about 130 words
rs58922911, also known as c.176T>G, p.Leu59Arg and L59R, represents a rare variant in the LMNA gene on chromosome 1. In ClinVar, the rs58922911(G) allele is listed, linked to OMIM records citing two publications indicating it could be causative for a dominantly inherited form of cardiomyopathy. In gnomAD/ExAC, there is no listing for this variant, even though the region has been sequenced in over 100,000 individuals, so presumably it is a very rare variant. In Promethease reports from 23andMe data collected in mid-2017, over 10% of all reports contain the rs58922911(G;T) genotype, indicating this SNP is quite likely to be routinely miscalled on the DNA chip in use by that company (and most likely by other companies using similar technology).
Source and license
Adapted from rs58922911 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.