rs6006460

A SNP in the PNPLA3 gene on chromosome 22. Its most notable genotype is G;T: lower liver triglyceride (fat) levels

Gene
PNPLA3
Location
Chr 2243,946,294 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
3%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GGoodcommon in complete genomicsTypical · 0.086% of people
  2. G;TMost notableGoodlower liver triglyceride (fat) levelsMinor · 1.514% of people
  3. T;TGoodlower liver triglyceride (fat) levelsMinor · 1.5<1% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 7 HapMap populations.

  • AverageG;G 86% G;T 14% T;T <1%
  • European ancestry (Utah)G;G 100% G;T 0% T;T 0%
  • Han Chinese (Beijing)G;G 100% G;T 0% T;T 0%
  • Japanese (Tokyo)G;G 100% G;T 0% T;T 0%
  • Yoruba (Nigeria)G;G 78% G;T 21% T;T 2%
  • African ancestry (Southwest US)G;G 70% G;T 30% T;T 0%
  • Luhya (Kenya)G;G 70% G;T 29% T;T <1%
  • Maasai (Kenya)G;G 85% G;T 15% T;T 0%

Other PNPLA3 SNPs

All PNPLA3 SNPs

Notes

From SNPedia

Notes

nature rs6006460(T) (S453I) lower hepatic fat content; by an average of 18% compared to the common (G;G) genotypes, at least as measured in African-Americans sampled.

Source and license

Adapted from rs6006460 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.