rs6012564

A SNP in the ARFGEF2 gene on chromosome 20. Its most notable genotype is A;A: normal

Gene
ARFGEF2
Location
Chr 2048,925,063 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodnormalTypical · 0.041% of people
  2. A;GBadSlightly increased proneness to anger?Typical · 0.046% of people
  3. G;GBadSlightly (1.25x) increased proneness to anger?Typical · 0.013% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 41% A;G 46% G;G 13%
  • European ancestry (Utah)A;A 37% A;G 47% G;G 16%
  • Han Chinese (Beijing)A;A 53% A;G 37% G;G 10%
  • Japanese (Tokyo)A;A 48% A;G 40% G;G 12%
  • Yoruba (Nigeria)A;A 51% A;G 38% G;G 11%
  • African ancestry (Southwest US)A;A 47% A;G 46% G;G 7%
  • Chinese (Denver)A;A 33% A;G 56% G;G 11%
  • Gujarati IndianA;A 28% A;G 58% G;G 14%
  • Luhya (Kenya)A;A 54% A;G 45% G;G 2%
  • Mexican ancestry (Los Angeles)A;A 33% A;G 45% G;G 22%
  • Maasai (Kenya)A;A 37% A;G 47% G;G 16%
  • TuscanA;A 31% A;G 46% G;G 23%

Notes

From SNPedia

Notes

Genome-Wide Association Study of Proneness to Anger: Table 1: Genome-Wide Association Results for the Angry Temperament subscale shows the Beta value (.12) for rs6012564, at least among 8,747 Caucasian 45-64 year olds.

A;G

Based on one 2013 study; see rs6012564

G;G

Based on one 2013 study; see rs6012564

Source and license

Adapted from rs6012564 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.