rs603965

A SNP in the CCND1 gene on chromosome 11. Its most notable genotype is A;A: normal

Gene
CCND1
Location
Chr 1169,648,142 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, FamilyTreeDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratednormalTypical · 0.019% of people
  2. A;GNot rated?Typical · 0.042% of people
  3. G;GNot ratedincreased breast cancer riskTypical · 0.039% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 19% A;G 42% G;G 39%
  • European ancestry (Utah)A;A 30% A;G 41% G;G 29%
  • Han Chinese (Beijing)A;A 34% A;G 45% G;G 21%
  • Japanese (Tokyo)A;A 18% A;G 55% G;G 27%
  • Yoruba (Nigeria)A;A 3% A;G 29% G;G 68%
  • African ancestry (Southwest US)A;A 4% A;G 42% G;G 54%
  • Chinese (Denver)A;A 38% A;G 42% G;G 20%
  • Gujarati IndianA;A 36% A;G 41% G;G 24%
  • Luhya (Kenya)A;A 2% A;G 39% G;G 59%
  • Mexican ancestry (Los Angeles)A;A 19% A;G 38% G;G 43%
  • Maasai (Kenya)A;A 3% A;G 39% G;G 59%
  • TuscanA;A 27% A;G 50% G;G 24%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs603965 is a SNP in the cyclin D1 CCND1 gene. It is also known as Pro241Pro. The associated genotypes are characterized in terms of their enzymatic activity as High for (A;A), Medium (A;G), and Low (G;G). In a study of 2 populations of breast cancer patients (2,000+ patients), increased risk was associated with rs603965(A;A) genotypes in both the Ontario [odds ratio 2.22, CI: 1.49-3.28] and Finland [OR 1.73, CI: 1.08-2.78] populations.

Source and license

Adapted from rs603965 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.