rs6094710

A SNP on chromosome 20. Its most notable genotype is A;A: 1.3x risk of osteoarthritis

Gene
None listed
Location
Chr 2047,466,905 (GRCh38)
Highest magnitude
1.3Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad1.3x risk of osteoarthritisMinor · 1.30% of people
  2. A;GBad1.3x risk of osteoarthritisMinor · 1.35% of people
  3. G;GNot ratedNo increased risk of osteoarthritisMinor · 1.095% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A 0% A;G 5% G;G 95%
  • European ancestry (Utah)A;A 0% A;G 6% G;G 94%
  • Han Chinese (Beijing)A;A 0% A;G 0% G;G 100%
  • Japanese (Tokyo)A;A 0% A;G 0% G;G 100%
  • Yoruba (Nigeria)A;A 0% A;G 13% G;G 87%

Conditions, medicines and genes

Notes

From SNPedia

Notes

2014 study of 11,277 cases of radiographic and symptomatic hip osteoarthritis (OA). "One locus, at 20q13, represented by rs6094710 (minor allele frequency (MAF) 4%) near the NCOA3 (nuclear receptor coactivator 3) gene, reached genome-wide significance level with p=7.9×10(-9) and OR=1.28 (95% CI 1.18 to 1.39) in the combined analysis of discovery (p=5.6×10(-8)) and follow-up studies (p=7.3×10(-4)). We showed that this gene is expressed in articular cartilage and its expression was significantly reduced in OA-affected cartilage." (Abstract)

Source and license

Adapted from rs6094710 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.