rs6166

A SNP in the FSHR gene on chromosome 2. Its most notable genotype is C;C: Females slightly more likely to be sterile

Gene
FSHR
Location
Chr 248,962,782 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
40%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TGoodcommon/normalTypical · 0.038% of people
  2. C;TNot ratednormal riskTypical · 0.047% of people
  3. A;GNot ratedNo summary available.Typical · 0.00% of people
  4. C;CMost notableBadFemales slightly more likely to be sterileMinor · 1.015% of people
  5. A;ANot ratedNo summary available.Typical · 0.00% of people

SNPedia records rs6166 on the minus strand: (A;A), (A;G), (C;T), (G;G), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 38% C;T 47% A;G 0% C;C 15% A;A 0%
  • European ancestry (Utah)T;T 35% C;T 49% A;G 0% C;C 16% A;A 0%
  • Han Chinese (Beijing)T;T 51% C;T 42% A;G 0% C;C 7% A;A 0%
  • Japanese (Tokyo)T;T 41% C;T 48% A;G 0% C;C 11% A;A 0%
  • Yoruba (Nigeria)T;T 25% C;T 52% A;G 0% C;C 23% A;A 0%
  • African ancestry (Southwest US)T;T 36% C;T 46% A;G 0% C;C 18% A;A 0%
  • Chinese (Denver)T;T 48% C;T 44% A;G 0% C;C 8% A;A 0%
  • Gujarati IndianT;T 24% C;T 51% A;G 0% C;C 26% A;A 0%
  • Luhya (Kenya)T;T 43% C;T 44% A;G 0% C;C 13% A;A 0%
  • Mexican ancestry (Los Angeles)T;T 40% C;T 55% A;G 0% C;C 5% A;A 0%
  • Maasai (Kenya)T;T 40% C;T 45% A;G 0% C;C 15% A;A 0%
  • TuscanT;T 31% C;T 44% A;G 0% C;C 26% A;A 0%

Other FSHR SNPs

All FSHR SNPs

Notes

From SNPedia

Notes

rs6166, also known as Asn680Ser or c.2039G>A, is a SNP in the follicle stimulating hormone receptor FSHR gene. rs6166(G) is the risk allele encoding the Ser amino acid, at least based on one study in which less fecund women were found to be disproportionately Ser/Ser homozygotes (i.e. rs6166(G;G) homozygotes; p=0.0035).

Source and license

Adapted from rs6166 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.