rs61742739
A SNP in the SLC5A2 gene on chromosome 16. Its most notable genotype is G;G: renal glycosuria possible, but see discussion
- Gene
- SLC5A2
- Location
- Chr 1631,490,477 (GRCh38)
- Highest magnitude
- 2.8Worth knowing
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- <1%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AGoodcommon in clinvar
- A;GBadcarrier of a possible allele for renal glycosuria
- G;GMost notableBadrenal glycosuria possible, but see discussion
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Notes
From SNPedia
Show notes, about 140 words
rs61742739, also known as c.1961A>G, p.Asn654Ser and N654S, represents a rare variant in the SLC5A2 gene on chromosome 16. Mutations in the SLC5A2 gene are reported to cause a familial form of renal glycosuria, with both dominant and recessive forms of inheritance reported. The rs61742739(G) allele was reported along with another SLC5A2 mutation in a patient with glycosuria, implying it is recessive, which was also consistent in that the patient's parents, one of whom was heterozygous for rs61742739(G), were not reported as having glycosuria. However, GET-Evidence states that some authors believe this variant is nonpathogenic. The literature cited is consistent with this variant being either benign or recessive (and possibly of variable penetrance).
A;G
see discussion at rs61742739
G;G
see discussion at rs61742739
Source and license
Adapted from rs61742739 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.