rs619203

A SNP in the ROS1 gene on chromosome 6. Its most notable genotype is C;G: increases susceptibility to Myocardial Infarction 1.15 times

Gene
ROS1
Location
Chr 6117,301,021 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
16%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GNot ratedNo summary available.Typical · 0.099% of people
  2. C;GMost notableBadincreases susceptibility to Myocardial Infarction 1.15 timesMinor · 1.5<1% of people
  3. C;CNot ratedNo summary available.Typical · 0.00% of people

SNPedia records rs619203 on the minus strand: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 99% C;G <1% C;C 0%
  • European ancestry (Utah)G;G 97% C;G 3% C;C 0%
  • Han Chinese (Beijing)G;G 100% C;G 0% C;C 0%
  • Japanese (Tokyo)G;G 100% C;G 0% C;C 0%
  • Yoruba (Nigeria)G;G 100% C;G 0% C;C 0%

Other ROS1 SNPs

All ROS1 SNPs

Notes

From SNPedia

Show notes, about 130 words

The G->C (Cys2229Ser) polymorphism (rs619203) of the ROS1 gene was significantly associated with atherothrombotic cerebral infarction in a study of 3,400+ Japanese adults. An independent study of 3657 patients with myocardial infarction (885 women and 2772 men) and 1211 control individuals (598 women and 613 men) did not observe any correlation to this SNP. rs619203 increases susceptibility to Myocardial Infarction 1.15 times for heterozygotes (CG) and 1.75 times for homozygotes (TT) Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia. ROS1 Asp2213Asn polymorphism is not associated with coronary artery disease in a Greek case-control study.

Source and license

Adapted from rs619203 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.